Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance
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چکیده
منابع مشابه
Stimulation of autoimmunity by toll-like receptor ligands.
H ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant selfpeptides—for example, myelin-basic protein (MBP) peptides. Yet, autoimmunity in a given individual is a rare event indicating that the self-reactive cells are somehow prevented from inflicting damage. Various experiments in which transgenic animals express both peripheral antigen and its cogn...
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Glomerulonephritis can be exacerbated by infection. This study investigated the effect of N-palmitoyl-S-(2,3-bis(palmitoyloxy)-(2R,S)-propyl)-(R)-cysteinyl-seryl-(lysyl)3-lysine (Pam3CysSK4), a synthetic Toll-like receptor 2 (TLR2) ligand, that was given at immunization on disease severity in accelerated nephrotoxic nephritis. Stimulation of TLR by microbial constituents is known to influence t...
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The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair. Toll-like receptor 4 (TLR4) is a member of a highly conserved receptor family and is a critical activator of the innate immune response after tissue injury. TLR4 signaling has been shown to regulate the sys...
متن کاملSpecies-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.
BACKGROUND Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1 or TLR6. The role of those coreceptors in Aspergillus sensing is unknown. METHODS Cytokine production was measured in bone marrow-derived mac...
متن کاملToll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients
Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading to CNS autoimmunity and neurodegenerative diseases. Objective: To find a relationship between M...
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ژورنال
عنوان ژورنال: Lupus Science & Medicine
سال: 2018
ISSN: 2053-8790
DOI: 10.1136/lupus-2018-000259